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Drug intelligence / Profile preview
[18F]fluoro-L-TIC(OH)
- Development stage
- Preclinical
- Lead developer
- Inserm
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Small Molecules
- Administration
- Intravenous
01
Overview
[18F]fluoro-L-TIC(OH) is a fluorine-18 radiolabeled cyclic tyrosine analogue under preclinical development as a positron emission tomography (PET) imaging radiotracer for solid tumors, particularly prostate cancer. It is designed to target amino acid transporters, specifically L-type amino acid transporter 1 (LAT1), which are highly upregulated in various malignancies to support rapid tumor growth and metabolism. The radiotracer is synthesized via copper-mediated radiofluorination of organotin precursors.
- Other names
- [18F]5-fluoro-L-TIC(OH)[18F]6-fluoro-L-TIC(OH)[18F]8-fluoro-L-TIC(OH)[18F]fluoro-L-1,2,3,4-tetrahydro-7-hydroxyisoquinoline-3-carboxylic acidfluoro-L-TIC(OH)
02
Targets
SLC7A5 (Large neutral amino acid transporter small subunit 1)
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